Current Treatment Options for Acute Skin and Skin-structure Infections
نویسندگان
چکیده
منابع مشابه
Early endpoints for acute bacterial skin and skin structure infections.
In this issue of the journal, Friedland et al. (4) present a retrospective analysis of the two CANVAS trials (3), employing the newer endpoints from the U.S. Food and Drug Administration (FDA) (7). First, they are to be congratulated for having the foresight to include sufficient measurements in their trial to allow the reanalysis even prior to the issuance of the new guidelines. The analysis e...
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treatment that allows pathogenic bacteria to multiply on the skin. Uncomplicated SSSIs can occur in the various layers of the skin (Figure 1) and in underlying tissue, and they are classified as primary infections, such as impetigo, or as secondary infections of existing lesions, which include atopic dermatitis, allergic contact dermatitis, and psoriasis. Infections occurring in lacerations, su...
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Dalbavancin is a novel parenteral lipoglycopeptide antibiotic approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) in adults. Dalbavancin is highly active against common Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Dalbavancin has a prolonged half-life that allows for once weekly dosing. Phase III trials have demons...
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The emergence of resistance to glycopeptide antibiotics such as vancomycin and teicoplanin among Gram-positive bacteria has spurred the search for second-generation drugs of this class. Oritavancin, a promising novel, second-generation, semisynthetic lipoglycopeptide, is distinguished by two mechanisms of action: inhibition of cell wall synthesis and disruption of the cell membrane. This dual m...
متن کاملClinical efficacy of dalbavancin for the treatment of acute bacterial skin and skin structure infections (ABSSSI)
Acute bacterial skin and skin structure infections (ABSSSI) are a common disease causing patients to seek treatment through the health care system. With the continued increase of drug-resistant bacterial pathogens, these infections are becoming more difficult to successfully cure. Lipoglycopeptides have unique properties that allow the drug to remain active toward both common and challenging pa...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2019
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/ciz004